Moreover, sleep deprivation alters appetite-regulating hormones and increases caloric intake 2, 3. Mounting epidemiological data implicates sleep loss as a risk factor for obesity in both children and adults worldwide 1. These findings provide an explanatory brain mechanism by which insufficient sleep may lead to the development/maintenance of obesity through diminished activity in higher-order cortical evaluation regions, combined with excess subcortical responsivity in the amygdala, resulting in selection of foods most capable of triggering weight-gain. Moreover, this bi-directional change in the profile of brain activity is further associated with a significant increase in the desire for weight-gain promoting high-calorie foods following sleep deprivation, the extent of which is predicted by the subjective severity of sleep loss across participants. Here we report that sleep deprivation significantly decreases activity in appetitive evaluation regions within the human frontal cortex and insula cortex during food desirability choices, combined with a converse amplification of activity within the amygdala. However, the detrimental impact of sleep deprivation on central brain mechanisms governing appetitive food desire remains unknown.
Epidemiological evidence supports a link between sleep loss and obesity.
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